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1

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Burton, Paul R, Clayton, David G, Cardon, Lon R, Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P, McCarthy, Mark I, Ouwehand, Willem H, Samani, Nilesh J

Journal:

Nature Genetics

Year:

2007

Language:

english

File:

PDF, 364 KB

english, 2007

2

Soil amendment with biochar increases the competitive ability of legumes via increased potassium availability

Oram, Natalie J., van de Voorde, Tess F.J., Ouwehand, Gert-Jan, Bezemer, T. Martijn, Mommer, Liesje, Jeffery, Simon, Groenigen, Jan Willem Van

Journal:

Agriculture, Ecosystems & Environment

Year:

2014

Language:

english

File:

PDF, 690 KB

english, 2014

3

Saturation analysis for whole-genome bisulfite sequencing data

Libertini, Emanuele, Heath, Simon C, Hamoudi, Rifat A, Gut, Marta, Ziller, Michael J, Herrero, Javier, Czyz, Agata, Ruotti, Victor, Stunnenberg, Hendrik G, Frontini, Mattia, Ouwehand, Willem H, Meissn

Journal:

Nature Biotechnology

Year:

2016

Language:

english

File:

PDF, 778 KB

english, 2016

4

Comparison of Methods for Competitive Tests of Pathway Analysis

Evangelou, Marina, Rendon, Augusto, Ouwehand, Willem H., Wernisch, Lorenz, Dudbridge, Frank, Mailund, Thomas

Journal:

Year:

2012

Language:

english

File:

PDF, 322 KB

english, 2012

5

Characterization of human variable domain antibody fragments against the U1 RNA-associated A protein, selected from a synthetic and a patient-derived combinatorial V gene library

Ruud M. T. de Wildt, Ricarda Finnern, Willem H. Ouwehand, Andrew D. Griffiths, Walther J. van Venrooij, René M. A. Hoet

Journal:

European Journal of Immunology

Year:

1996

Language:

english

File:

PDF, 1.14 MB

english, 1996

6

Improving the power to detect differentially expressed genes in comparative microarray experiments by including information from self–self hybridizations

Arief Gusnanto, Brian Tom, Philippa Burns, Iain Macaulay, Daphne C. Thijssen-Timmer, Marloes R. Tijssen, Cordelia Langford, Nicholas Watkins, Willem Ouwehand, Carlo Berzuini, Frank Dudbridge

Journal:

Computational Biology and Chemistry

Year:

2007

Language:

english

File:

PDF, 328 KB

english, 2007

7

Prebiotics and other microbial substrates for gut functionality

Arthur C Ouwehand, Muriel Derrien, Willem de Vos, Kirsti Tiihonen, Nina Rautonen

Journal:

Current Opinion in Biotechnology

Year:

2005

Language:

english

File:

PDF, 125 KB

english, 2005

8

Platelet αIIbβ3 recombinant autoantibodies from the B-cell repertoire of a post-transfusion purpura patient

Nicholas A. Watkins, Peter A. Smethurst, David Allen, Graham A. Smith, Willem H. Ouwehand

Journal:

British Journal of Haematology

Year:

2002

Language:

english

File:

PDF, 363 KB

english, 2002

9

Activation during preparation of therapeutic platelets affects deterioration during storage: a comparative flow cytometric study of different production methods

PAUL METCALFE, LORNA M. WILLIAMSON, CHRIS P. M. REUTELINGSPERGER, IAN SWANN, WILLEM H. OUWEHAND, ALISON H. GOODALL

Journal:

British Journal of Haematology

Year:

1997

Language:

english

File:

PDF, 1017 KB

english, 1997

10

Synthesis of Rh Fv phage-antibodies using VH and VL germline genes

Nevin Hughes-Jones, Jacqueline Bye, Barbara Gorick, James Marks, Willem Ouwehand

Journal:

British Journal of Haematology

Year:

1999

Language:

english

File:

PDF, 138 KB

english, 1999

11

Introduction to Antibody Engineering and Phage Display

Nicholas A. Watkins, Willem H. Ouwehand

Journal:

Year:

2000

Language:

english

File:

PDF, 263 KB

english, 2000

12

Albert E.G. Kreutzwendedich von dem Borne

C. Paul Engelfriet, Willem Ouwehand, Ellen van der Schoot

Journal:

Transfusion (Wiley)

Year:

2003

Language:

english

File:

PDF, 61 KB

english, 2003

13

Teicoplanin-dependent antibodies: detection and characterization

Stephen F. Garner, Kate Campbell, Graham Smith, Colin Hurd, Simon J. Davidson, Marilyn Treacy, John F. Burman, Hartmut Kroll, Willem H. Ouwehand

Journal:

British Journal of Haematology

Year:

2005

Language:

english

File:

PDF, 65 KB

english, 2005

14

Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation

Lisa-Marie Holbrook, Nicholas A. Watkins, Alan D. Simmonds, Chris I. Jones, Willem H. Ouwehand, Jonathan M. Gibbins

Journal:

British Journal of Haematology

Year:

2010

Language:

english

File:

PDF, 713 KB

english, 2010

15

Microarray-based genotyping for blood groups: comparison of gene array and 5′-nuclease assay techniques with human platelet antigen as a model

Peter Bugert, Simon McBride, Graham Smith, Alex Dugrillon, Harald Klüter, Willem H. Ouwehand, Paul Metcalfe

Journal:

Transfusion (Wiley)

Year:

2005

Language:

english

File:

PDF, 140 KB

english, 2005

16

The dilemma of screening for antibodies against low-frequency human platelet antigens

Willem H. Ouwehand

Journal:

Transfusion (Wiley)

Year:

2005

Language:

english

File:

PDF, 45 KB

english, 2005

17

A naturally occurring Leu33Val mutation in β3-integrin impairs the HPA-1a epitope: the third allele of HPA-1

Sentot Santoso, Hartmut Kroll, Cornelia L. Andrei-Selmer, Ines Socher, Angela Rankin, Evelyne Kretzschmar, Nicholas A. Watkins, Willem H. Ouwehand

Journal:

Transfusion (Wiley)

Year:

2006

Language:

english

File:

PDF, 310 KB

english, 2006

18

Molecular characterization of the variable domains of an αIIbβ3-specific immunoglobulin M κ platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between αIIbβ3 integrin antibodies

Nicola S. Jennings, Ian J. Harmer, Kate Campbell, Prachi Stafford, Graham A. Smith, Paul Metcalfe, M. Ann Benton, Judith C.W. Marsh, Willem H. Ouwehand

Journal:

Transfusion (Wiley)

Year:

2007

Language:

english

File:

PDF, 421 KB

english, 2007

19

Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia

Cedric Ghevaert, Kate Campbell, Jill Walton, Graham A. Smith, Dave Allen, Lorna M. Williamson, Willem H. Ouwehand, Edmund Ranasinghe

Journal:

Transfusion (Wiley)

Year:

2007

Language:

english

File:

PDF, 317 KB

english, 2007

20

HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia

Cedric Ghevaert, Kate Campbell, Prachi Stafford, Paul Metcalfe, Angela Casbard, Graham A. Smith, Dave Allen, Edmund Ranasinghe, Lorna M. Williamson, Willem H. Ouwehand

Journal:

Transfusion (Wiley)

Year:

2007

Language:

english

File:

PDF, 404 KB

english, 2007

21

Apheresis donors and platelet function: inherent platelet responsiveness influences platelet quality

Stephen F. Garner, Chris I. Jones, Jonathan Stephens, Philippa Burns, Jill Walton, Adam Bernard, Will Angenent, Willem H. Ouwehand, Alison H. Goodall, BLOODOMICS Consortium

Journal:

Transfusion (Wiley)

Year:

2008

Language:

english

File:

PDF, 214 KB

english, 2008

22

A single-nucleotide polymorphism in the human ITGB3 gene is associated with the platelet-specific alloantigen Vaa (HPA-17bw) involved in fetal maternal alloimmune thrombocytopenia

Prachi Stafford, Stephen F. Garner, Angela Rankin, Riitta Kekomaki, Nicholas A. Watkins, Willem H. Ouwehand

Journal:

Transfusion (Wiley)

Year:

2008

Language:

english

File:

PDF, 323 KB

english, 2008

23

Detection of human platelet antigen-1a alloantibodies in cases of fetomaternal alloimmune thrombocytopenia using recombinant β3 integrin fragments coupled to fluorescently labeled beads

Winnie Chong, Paul Metcalfe, Rosey Mushens, Geoff Lucas, Willem H. Ouwehand, Cristina V. Navarrete

Journal:

Transfusion (Wiley)

Year:

2011

Language:

english

File:

PDF, 308 KB

english, 2011

24

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Burton, Paul R., Clayton, David G., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J.

Journal:

Year:

2007

Language:

english

File:

PDF, 4.11 MB

english, 2007

25

Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library

Marks, James D., Ouwehand, Willem H., Bye, Jacqueline M., Finnern, Ricarda, Gorick, Barbara D., Voak, Douglas, Thorpe, Susan, Hughes-Jones, Nevin C., Winter, Greg

Journal:

Year:

1993

File:

PDF, 1019 KB

1993

26

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

Floto, R Andres, Clatworthy, Menna R, Heilbronn, Karen R, Rosner, Dalya R, MacAry, Paul A, Rankin, Angela, Lehner, Paul J, Ouwehand, Willem H, Allen, Janet M, Watkins, Nicholas A

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

27

PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways

Chris I. Jones, Stephen F. Garner, Leonardo A. Moraes, William J. Kaiser, Angela Rankin, Willem H. Ouwehand, Alison H. Goodall, Jonathan M. Gibbins

Journal:

Year:

2009

Language:

english

File:

PDF, 757 KB

english, 2009

28

Image-based characterization of thrombus formation in time-lapse DIC microscopy

Nicolas Brieu, Nassir Navab, Jovana Serbanovic-Canic, Willem H. Ouwehand, Derek L. Stemple, Ana Cvejic, Martin Groher

Journal:

Medical Image Analysis

Year:

2012

Language:

english

File:

PDF, 4.50 MB

english, 2012

29

11 Immunology of platelet disorders

Albert E.G.Kr. Von Dem Borne, Willem H. Ouwehand

Journal:

Baillière's Clinical Haematology

Year:

1989

Language:

english

File:

PDF, 2.19 MB

english, 1989

30

Detection of platelet activation with monoclonal antibodies and flow cytometry. Changes during platelet storage

Rob Fijnheer, Piet W. Modderman, H. Veldman, Willem H. Ouwehand, H. Karel Nieuwenhuis, Dirk Roos, Dirk de Korte

Journal:

Transfusion (Wiley)

Year:

1990

Language:

english

File:

PDF, 546 KB

english, 1990

31

Acquired thrombasthenia due to GPIIbIIIa platelet autoantibodies in a 4-yr-old child

Adrian J. C. Bloor, Graham A. Smith, Mervyn Jaswon, Norman E. Parker, Willem H. Ouwehand, Ri Liesner

Journal:

European Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 107 KB

english, 2006

32

Expression of the Amino-Terminal Domain of Platelet Glycoprotein Ibα: Exploitation of a Calmodulin Tag for Determination of Its Functional Activity

Chester Q Li, Pei Ye, Zhao-feng Cao, Huifang Wang, Lan Lu, Peter Nicastro, Emma Wood, Justin J Robert, Willem H Ouwehand, Fergal Hill, José A López, Mark R Wardell

Journal:

Protein Expression and Purification

Year:

2001

Language:

english

File:

PDF, 225 KB

english, 2001

33

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

Nicola K. Wilson, Samuel D. Foster, Xiaonan Wang, Kathy Knezevic, Judith Schütte, Polynikis Kaimakis, Paulina M. Chilarska, Sarah Kinston, Willem H. Ouwehand, Elaine Dzierzak, John E. Pimanda, Marella

Journal:

Year:

2010

Language:

english

File:

PDF, 1.40 MB

english, 2010

34

Theoretic and Practical Aspects of Platelet Crossmatching

Albert E.G.Kr. von dem Borne, Willem H. Ouwehand, Robert W.A.M. Kuijpers

Journal:

Transfusion Medicine Reviews

Year:

1990

Language:

english

File:

PDF, 1.32 MB

english, 1990

35

Transcription factor co-localization patterns affect human cell type-specific gene expression

Wang, Dennis, Rendon, Augusto, Ouwehand, Willem, Wernisch, Lorenz

Journal:

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

36

Characteristics of graft-infiltrating lymphocytes after human heart transplantation HLA mismatches and the cellular immune response within the transplanted heart

Ouwehand, Alice J., Baan, Carla C., Vaessen, Leonard M.B., Jutte, Nicolet H.P.M., Balk, Aggie H.M.M., Bos, Egbert, Claas, Frans H.J., Weimar, Willem

Journal:

Human Immunology

Year:

1994

Language:

english

File:

PDF, 802 KB

english, 1994

37

New insights into the genetic basis of TAR (thrombocytopenia-absent radii) syndrome

Albers, Cornelis A, Newbury-Ecob, Ruth, Ouwehand, Willem H, Ghevaert, Cedric

Journal:

Current Opinion in Genetics & Development

Year:

2013

Language:

english

File:

PDF, 1.25 MB

english, 2013

38

Investigating the role of rare genetic variants of GP6 gene in platelet function

Mitrofan, Claudia-Gabriela, Hansen, Sjoert, Smethurst, Peter, Ouwehand, Willem

Journal:

Year:

2014

Language:

english

File:

PDF, 63 KB

english, 2014

39

Expression of a single-chain human leukocyte antigen-DRA/DRB3*01:01 molecule and differential binding of a monoclonal antibody in the presence of specifically bound human platelet antigen-1a peptide

Bouwmans, Evelien E., Smethurst, Peter A., Garner, Stephen F., Ouwehand, Willem H., Morley, Sarah L.

Journal:

Transfusion (Elsevier)

Year:

2014

Language:

english

File:

PDF, 506 KB

english, 2014

40

Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation

Walker, Adam, Pugh, Nicholas, Garner, Stephen F., Stephens, Jonathan, Maddox, Ben, Ouwehand, Willem H., Farndale, Richard W., Steward, Michael, On Behalf of the Bloodomics consort,

Journal:

Year:

2009

Language:

english

File:

PDF, 827 KB

english, 2009

41

Identification of variation in the platelet transcriptome associated with Glycoprotein 6 haplotype

Burns, Philippa, Gusnanto, Arief, Macaulay, Iain C., Rankin, Angela, Tom, Brian, Langford, Cordelia F., Dudbridge, Frank, Ouwehand, Willem H., Watkins, Nicholas A.

Journal:

Year:

2008

Language:

english

File:

PDF, 348 KB

english, 2008

42

[IEEE 2012 IEEE 9th International Symposium on Biomedical Imaging (ISBI 2012) - Barcelona, Spain (2012.05.2-2012.05.5)] 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI) - Automatic segmentation and tracking of thrombus formation within in vitro microscopic video sequences

Peter, Loic, Brieu, Nicolas, Jansen, Sjoert, Smethurst, Peter A., Ouwehand, Willem H., Navab, Nassir

Year:

2012

Language:

english

File:

PDF, 377 KB

english, 2012

43

The intestinal mucosa as a habitat of the gut microbiota and a rational target for probiotic functionality and safety

Derrien, Muriel, Adawi, Diya, Ahrné, Siv, Jeppsson, Bengt, Molin, Göran, Osman, Nadia, Štšepetova, Jelena, Vaughan, Elaine E., de Vos, Willem M., Ouwehand, Arthur C.

Journal:

Microbial Ecology in Health and Disease

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

44

The INTERVAL trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial

Moore, Carmel, Sambrook, Jennifer, Walker, Matthew, Tolkien, Zoe, Kaptoge, Stephen, Allen, David, Mehenny, Susan, Mant, Jonathan, Angelantonio, Emanuele, Thompson, Simon G, Ouwehand, Willem, Roberts,

Journal:

Year:

2014

Language:

english

File:

PDF, 498 KB

english, 2014

45

αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia

Buitrago, Lorena, Rendon, Augusto, Liang, Yupu, Simeoni, Ilenia, Negri, Ana, Filizola, Marta, Ouwehand, Willem H., Coller, Barry S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

46

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

Maiwald, Stephanie, Motazacker, Mahdi M, van Capelleveen, Julian C, Sivapalaratnam, Suthesh, van der Wal, Allard C, van der Loos, Chris, Kastelein, John J P, Ouwehand, Willem H, Hovingh, G Kees, Trip,

Journal:

European Journal of Human Genetics

Year:

2015

Language:

english

File:

PDF, 1.55 MB

english, 2015

47

Cross-domain inhibition of TACE ectodomain

Tape, C. J., Willems, S. H., Dombernowsky, S. L., Stanley, P. L., Fogarasi, M., Ouwehand, W., McCafferty, J., Murphy, G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

48

A Loss of Function Screen of Identified Genome-Wide Association Study Loci Reveals New Genes Controlling Hematopoiesis

Bielczyk-Maczyńska, Ewa, Serbanovic-Canic, Jovana, Ferreira, Lauren, Soranzo, Nicole, Stemple, Derek L., Ouwehand, Willem H., Cvejic, Ana, Zon, Leonard I.

Journal:

Year:

2014

Language:

english

File:

PDF, 8.92 MB

english, 2014

49

Introduction to Antibody Engineering and Phage Display

Watkins, Nicholas A., Ouwehand, Willem H.

Journal:

Year:

2000

Language:

english

File:

PDF, 257 KB

english, 2000

50

Cross-domain inhibition of TACE ectodomain

Christopher J. Tape, Sofie H. Willems, Sarah L. Dombernowsky, Peter L. Stanley, Marton Fogarasi, Willem Ouwehand, John McCafferty, Gillian Murphy and James A. Wells

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011